Important general properties
The coefficients $(X^1(x),\dots,X^n(x))$ are the components of a vector field on $\Omega$.
The partial differential operator $D=X^\alpha(x)\partial_\alpha$ does not
depend on the coordinate systems. When we change coordinates
$x^\alpha\to x^{\alpha'}(x^\alpha)$ then (chain rule)
$$
\partial_{\alpha'} = \left(\partial_{\alpha'}x^\alpha\right)\partial_\alpha\,,
$$
so that
$$
X^\alpha = X^{\alpha'}\partial_{\alpha'}x^\alpha\,,
$$
that is exactly the change of coordinates rule for a vector.
Regularity of solutions
Assume that $v\in C^k(\Omega)$ and $h\in C^k(\Gamma)$. Then the local solution defined above
lies in $C^k(\Phi_X(\Gamma))$.
It is enough to prove it in coordinates. On $\Phi_X(\Gamma)$, $X$ is never zero so we can
find coordinates $(x^1,\dots,x^n)$ so that, in the whole $\Phi_X(\Gamma)$, $X=\partial_{x^1}$
and $h=h(x^2,\dots,x^n)$. In these coordinates the equation therefore writes
$$
\partial_{x^1}u=v\,,\;u(0,x^2,\dots,x^n)=h(x^2,\dots,x^n)
$$
whose solution is
$$
u(x^1,\dots,x^n) = \int_0^{x^1}v(t,\dots,x^n)dt + h(x^2,\dots,x^n)\,.
$$
If $v\in C^k(\Bbb R^n)$ and $h\in C^k(\Bbb R^{n-1})$, clearly $u\in C^k(\Bbb R^n)$.